is novavax safer than mrna

The Motley Fool has a disclosure policy. Whereas the last I heard of Moderna, I think it was one billion. How well it works on virus variants: The data presented to the FDA was gathered before Omicron or its recent subvariants started to circulate, but the company says it expects to have a vaccine that will protect against the recent Omicron subvariants in 2023. This technology is behind many of the routine childhood vaccinations for whooping cough, diphtheria, tetanus, and hepatitis B. In January, the New England Journal of Medicine (NEJM) published a study based on people 12 and older included in North Carolinas state vaccine registry data. The inflammation, in most cases, gets better on its own without treatment. "The mRNA platform is far more modifiable than what Novavax does," he said. With expert resources and tireless advocacy, the AMA is your powerful ally against COVID-19. Myocarditis, a rare form of inflammation of the heart muscle, occurred in a handful of Novavax clinical trial participants, all of whom were men. The study found the bivalent vaccine to be 58.7% effective against hospitalization compared to 25% for the monovalent one that preceded it; its effectiveness against infection was 61.8% compared to 24.9% for the monovalent. The inflammation, in most cases, If we need additional booster shots in the future, it will be important for us to have an appropriate vaccine supply here in the U.S.. Not as quick. Thats where I think the real benefit is going to come from, in reducing the burden on our hospitals and saving more lives over time.. Learn more about the process with the AMA. For this reason, mRNA vaccines are easier to adjust than Novavax when a new variant comes along, Kedl said. Company executives and some public health officials have expressed hope that this recombinant protein-based vaccine will be more palatable to the vaccine-hesitant than existing vaccines using new (and therefore scarier) mRNA and adenovirus Possible side effects:Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. Robert Malone promoted it as better than the mRNA vaccines. Its technology has been used before in vaccines to prevent such conditions as shingles, human papillomavirus, and DTaP (diphtheria, tetanus, and pertussis), among others. How does it stack up to Moderna and Pfizer's mRNA vaccines? The Pfizer-BioNTech and Moderna COVID-19 vaccines use a newer mechanism in which messenger RNA is used to lead cells to create a protein on the virus surface that the immune system It uses the spike proteins themselves so our body can recognize and fight the virus when we are exposed to it in the future. Explore top articles, videos, research highlights and more from the AMAyour source for clear, evidence-based news and guidance during the pandemic. The Pfizer-BioNTech vaccine (brand name: Comirnaty) was granted full Food and Drug Administration (FDA) approval in August 2021 for people ages 16 and older. I often tell people, imagine an eggshell without an egg in it. This type of vaccine uses genetically engineered mRNA to give your cells instructions for how to make the S protein found on the surface of the COVID-19 virus. The most commonly reported side effects by vaccine recipients in the clinical trial were pain/tenderness, redness and swelling at the injection site, fatigue, muscle pain, headache, joint pain, nausea/vomiting, and fever. But what's behind this difference in side effects? How it works:Similar to the Pfizer vaccine, this is an mRNA vaccine that sends the bodys cells instructions for making a spike protein that will train the immune system to recognize it. How it works: It uses mRNA technology, which is a new type of vaccine. This article was reviewed by Yale Medicine infectious diseases specialistJaimie Meyer, MD, MS. Information to help you make your best choice. KFF COVID-19 vaccine monitor - April 2021. Alternatively, adults are eligible for a Pfizer-BioNTech or Moderna bivalent booster at least two months after their primary Novavax vaccination, and teenagers ages 12 through 17 must get a Pfizer-BioNTech bivalent booster. Psoriasis and COVID-19 Vaccine: What to Know, What to Know About the COVID-19 Vaccine If You Have Diabetes, Safety and efficacy of NVX-CoV2373 Covid-19 vaccine, KFF COVID-19 vaccine monitor - April 2021, Week 32 household pulse survey: June 9 June 21. Access reports from the Council on Medical Education presented during the AMA Annual and Interim Meetings. The information in this article is current as of the date listed, which means newer information may be available when you read this. An 8-week interval is recommended between primary series doses of NVX-CoV2373. Though COVID vaccines may utilize different delivery mechanisms, the end result is the same: cells in the body recognize that a spike protein (the spikes you see sticking out of the coronavirus in pictures) doesnt belong, and the immune system reacts by activating immune cells and producing antibodies to attack the real virus if you get exposed. How is Novavax different from the other COVID vaccines? There was no comparative data for the CoronaVac vaccine in the latest HSA report, its 12th on the roll-out of COVID-19 vaccines in Singapore. Also, there's no problem giving Novavax or any of the other COVID vaccines with other vaccines with one exception: orthopoxvirus vaccines, she added, noting that while we're in the middle of a monkeypox outbreak ACAM2000 and JYNNEOS are the two vaccines available for orthopoxvirus viruses.. COVID-19 infection is also known to be associated with myocarditis, with 40 extra myocarditis events per million persons observed among those infected with the virus based on published data, according to HSA. Will Novavax have a longer shelf life in the immune system? Note: None of the COVID-19 vaccines changeor interact witha recipients DNA. The Novavax Covid-19 vaccine, which goes by the Scrabble-friendly trade name Nuvaxovid, has been authorized as a two-dose primary series given three weeks. The study found the bivalent vaccine to be 58.7% effective against hospitalization compared to 25% for the monovalent one that preceded it; its effectiveness against infection was 61.8% compared to 24.9% for the monovalent. With the mRNA vaccines, particularly in older people, the duration of immune response seems to fall off after four to six months, Dr. Wilson says, adding that there is now data to show this is the case with Omicron. The mRNA vaccines, like Pfizer and Moderna , contain a piece of genetic code called RNA that the body creates an immune response for. Most of the cases occurred within 42 days after vaccination. Dosages for children are different than dosages for adults. Thats what it is, Dr. Wilson says. The overall efficacy of these three vaccines is similar, ranging between around 90% to 95%, Yildirim adds. Novavax's vaccine uses a traditional mechanism as compared to mRNA vaccines. FDA warnings: The FDA added a warning label on the mRNA vaccines regarding serious (but rare) cases of inflammation of the heart muscle (myocarditis) and of the outer lining of the heart (pericarditis) in adolescents and young adults, more often occurring after the second dose of an mRNA vaccine. The shots also appear to be safe. Navigating the COVID-19 Pandemic With Rheumatoid Arthritis. How is Novavax different from the other COVID vaccines? iPhone or Finally, in November 2021, countries around the world, starting with Indonesia and the Philippines, later followed by the United Kingdom, began granting authorizations for the vaccine. In January, the New England Journal of Medicine (NEJM) published a study based on people 12 and older included in North Carolinas state vaccine registry data. Another study in January from the CDC assessed the bivalent vaccines effectiveness against the most recent Omicron subvariants, XBB and XBB.1.5, in people who had previously received two to four monovalent vaccine doses, and found it to be similar to how well it worked against BA.5 for at least the first three months after vaccination. This vaccine, which is a protein adjuvant, had a 90% efficacy in its clinical trial, performing almost as well as the mRNA vaccines in their early trials. As the SARS-CoV-2 virus mutates and new variantscontinue to emerge, its important to keep up with how well the vaccines are performing, but its also a daunting task, given the flood of information (and misinformation) coming at us from so many directions. Updated:Oct. 20, 2022.]. Messenger RNA (mRNA) vaccine. Peter McCullough said it would be a safer vaccine . Unfortunately, ACAM2000 has been linked to myocarditis. We know that the risk of heart complications is higher after COVID disease than after mRNA COVID vaccination among males and females of all ages. Both Pfizers and Modernas vaccines use messenger RNA (mRNA) to deliver a blueprint of sorts to cells in the body. The company also announced that it started a study in May looking at Novavax boosters after an mRNA primary vaccine series, Dr. Fryhofer explained. Novavax is a different type of COVID-19 vaccine than what has been previously approved or authorized in the U.S. It comes in 10-dose vials, and it's preservative free. As with other COVID-19 vaccines, breakthrough cases, in which someone who is vaccinated still gets infected with COVID-19, remain a reality. We have experience with this well-established technology and these vaccines are relatively very stable, Inci Yildirim, MD, PhD, vaccinologist and pediatric infectious diseases specialist at Yale Medicine and associate professor of pediatrics and global health at the Yale School of Medicine, tells Verywell. After a second dose of the Pfizer vaccine : 66% reported pain The Novavax vaccine (brand names: Nuvaxovid and Covovax) was the fourth COVID-19 vaccine to be administered in the U.S. The biggest difference is the way the vaccine works. It's fine to give flu shots and COVID vaccines at the same time, and that also goes for the Novavax vaccine. Vaccine efficacy in this older group was 79%. Some employers are offering paid time off for COVID-19 vaccine appointments and subsequent recovery days. Both Pfizers and Modernas vaccines use messenger RNA (mRNA) to deliver a blueprint of sorts to cells in the body. I think Pfizer's manufacturing all their stuff in-house, and Moderna, I believe, is farming it out to other people, but it's very complicated. If any of these side effects occur, they should go away in a few days. It remains to be seen whether this report of fewer side effects holds up in a real-world setting. Theres some good news about coadministration of flu and COVID-19 vaccines, said Dr. Fryhofer. If you haven't been vaccinated yet and you're concerned about losing a day's worth of pay, it's best to check with your employer. But experts have pointed to an additional interesting tidbit in the research: This new vaccine may cause fewer side effects than those currently available in the U.S. A two-dose series of Novavax protein subunit COVID vaccine is now recommended for unvaccinated individuals who are 12 or older for primary vaccination against COVID-19., But it is important to note that Novavax has to be used for both doses in the primary series, she said. [laughs] I can't pronounce this. The good news is that vaccines are still expected to be effective at preventing severe disease, hospitalization, and death from COVID-19. The Novavax booster targets the original SARS CoV-2 virus and may not protect against infection by Omicrons recent subvariants. In accordance with the WHO Prioritization Roadmap, Early last month, the pharmaceutical company Novavax shared that its two-dose COVID-19 vaccine was more than 90% effective at preventing COVID-19. We mapped out a comparison of the most prominent COVID-19 vaccines. Heres What We Know. The AMA promotes the art and science of medicine and the betterment of public health. One is that this is an additional vaccine choice that may be acceptable to some of the more than 30% of Americans who are not fully vaccinated, he explains. We don't know if there's an increased risk of myocarditis with JYNNEOS yet, but if you've received a dose of one of these orthopox vaccines, CDC suggests waiting four weeks to get a COVID vaccine dose, Dr. Fryhofer explained. With the mRNA vaccines, the inflammation, in most cases, gets better on its own without treatment. It uses the spike proteins themselves, in the form of nanoparticles, to trigger an immune response. A few side effects are serious, but rare. By Carla Delgado With the approval of Novavax, healthcare providers and individuals would have more options to choose from, which may increase national and global demand. The Novavax Covid-19 vaccine, which goes by the Scrabble-friendly trade name Nuvaxovid, has been authorized as a two-dose primary series given three weeks. Or does it actually have some advantages in the rest of the world? In November 2022, Pfizer announced that a clinical trial showed levels of neutralizing antibodies in the bivalent booster were fourfold higher in people 55 and older than in people of similar ages who got a monovalent booster, which targeted only the original virus. The HOD speakers welcome comments for reports under development for the upcoming Interim and Annual Meetings. Peter McCullough said it would be a safer vaccine . Android, The best in medicine, delivered to your mailbox. For some people older than 12, especially boys and men between ages 12 and 39, the CDC suggests an eight-week interval between the two shots to reduce the risk of myocarditis, an uncommon side effect (see FDA warnings below). were also circulating, which suggests the updated vaccine is more effective against those strains in addition to the ones it was designed to target. Novavaxs vaccine has gained a cult following on social media sites like Reddit and Twitter because it uses protein-based technology rather than the relatively new mRNA technology, Fortune reported. Therefore, these clinical trial results may be especially appealing to people who have concerns about loss of income due to sick days or potential time away from work due to vaccine side effects and/or complications.. A Novavax Booster Is Here. According to recent Census Bureau data, more than half of unvaccinated Americans live in households that make less than $50,000 annually. Possible side effects: The side effects are similar to Pfizer-BioNTechs vaccine: Pain, redness, or swelling at the site where the shot was administeredand/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. There's some data suggesting that certain proteins in the heart look like spike proteinsbut it doesn't look that much like a spike protein, so why certain individuals have more of a reaction than others is still not clear, says Dr. Wilson. The Pfizer-BioNTech and Moderna COVID-19 vaccines use a newer mechanism in which messenger RNA is used to lead cells to create a protein on the virus surface that the immune system They will be eligible for a booster shot five months later and can choose either a Moderna or Pfizer-BioNTech booster in most cases. We regret the error. Novavax is not available for boosters yet. Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years experience in consumer-oriented health and wellness content. I verify that Im in the U.S. and agree to receive communication from the AMA or third parties on behalf of AMA. It uses a different technology. They discover the molecules very fast. All of the cases with appendicitis were discharged after hospitalisation. While there have been no local reports of myocarditis or inflammation of heart muscles arising from Nuvaxovid doses, a small number of such cases have been observed from ongoing global clinical trials, said HSA. They have a similar safety profile, and a similar efficacy profiles, very high efficacy in all three of these vaccines. Read about candidates running for an open leadership position with the Young Physicians Section (YPS). Globally, we continue to learn about new variants of the COVID-19 virus, and we are still learning more about long-term vaccine effectiveness over time. Making the world smarter, happier, and richer. Examining the specific parts of a viral or bacterial pathogen to include in a subunit vaccine is a tedious process. To look for available vaccine appointments near you, visit Vaccines.gov. This inflammation may occur in the heart muscle (myocarditis) or in the outer lining of the heart (pericarditis)it more often occurs after the second dose of an mRNA vaccine. Now, in the Novavax clinical safety study, there were only four to six cases identified out of more than 40,000 vaccine recipients. The Novavax vaccine is a traditional one compared to the other vaccines. 10 stocks we like better than Novavax When our award-winning analyst team has a stock tip, it can pay to listen. In August, authorization for the vaccine was expanded to include adolescents ages 12 to 17, based on data from Novavaxs ongoing pediatric trial. Who can get the booster: The Novavax booster protects against the original SARS CoV-2 virus and may not protect against recent Omicron subvariants. The shots also appear to be safe. But whether the Novavax vaccine is less likely to cause side effects or not, having a potential fourth COVID-19 vaccine in the U.S. is still beneficial. It works by sending instructions to host cells in the body for making copies of a spike protein (like the spikes you see sticking out of the coronavirus in pictures). Heath PT, Galiza EP, Baxter DN, et al. If a vaccine like Novavax that causes fewer or less severe side effects becomes available, vaccination rates may increase among people in lower-income communities who can't afford to miss a days worth of pay. You store it at regular refrigerator temperatures but don't freeze it. The Novavax clinical trial was conducted before the Omicron variant was circulating, so data doesnt show how well the vaccine works against recent subvariants. The shell and the code cant make you sick, but once the code is inside the cells, the cells produce a spike protein to train the bodys immune system, which creates antibodies and memory cells to protect against an actual SARS-CoV-2 infection. Novavax's vaccine uses a traditional mechanism as compared to mRNA vaccines. More information for immunocompromised people is available on theCDC website. More information for immunocompromised individuals is available on theCDC website. They are also relatively cheap and easy to produce. But in the spring of 2021, concerns over rare blood clots associated with the vaccine prompted the government to put a pause on it, which was soon lifted. Before that, it was the firstCOVID-19 vaccineto receive FDA Emergency Use Authorization (EUA) back in December 2020, after the company reported that its vaccine was highly effective at preventing symptomatic disease. An 8-week interval is recommended between primary series doses of NVX-CoV2373. Carmichael: Nanoparticle. This causes your body to create The Novavax Covid-19 vaccine, which goes by the Scrabble-friendly trade name Nuvaxovid, has been authorized as a two-dose primary series given three weeks. Dosage:For the primary series: two shots, 3-8 weeks apart. Messenger RNA (mRNA) vaccine. No dilutions necessary, but vaccine has to be discarded if it's not used within six hours after the first puncture of the vial., In the study, vaccine doses were administered three weeks apart. There are no specific data on extended intervals for Novavax and this is all based on the mRNA vaccine studies.. These include anaphylaxis, a severe reaction that is treatable with epinephrine (the drug in Epipens). A few side effects are serious, but rare. A dose is half a cc and contains 5 micrograms of protein subunit antigen along with 50 micrograms of a proprietary adjuvant Matrix-M, which boosts the immune response, said Dr. Fryhofer, adding it is given intramuscularly in the deltoid muscle., Novavax has several logistical advantages. In this installment, Sandra Fryhofer, MD, an Atlanta general internist and chair of the AMA Board of Trustees, discusses the Novavax COVID-19 vaccine. However, we can't directly compare myocarditis rates between Novavax and mRNA vaccines based on currently available data, Dr. Fryhofer added. Drive in style with preferred savings when you buy, lease or rent a car. Scientists noted that this study covered a period when Omicron subvariants BQ.1 and BQ.1.1. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. For this reason, mRNA vaccines are easier to adjust than Novavax when a new variant comes along, Kedl said. Learn more about gender discrimination in elite science. Eczema and the COVID-19 Vaccine: Is it Safe? Dosage: 2 doses, 3-8 weeks apart. Editor's Note:The below video and transcript contain an error. The main difference between the Novavax vaccine and the already-approved and widely used vaccines from Pfizer/BioNTech and Moderna is the technology behind the shots. Peter McCullough said it would be a safer vaccine . This causes your body to create Scientists engineer a harmless adenovirus (a common virus that, when not inactivated, can cause colds, bronchitis, and other illnesses) as a shell to carry genetic code on the spike proteins to the cells (similar to a Trojan Horse). The inflammation, in most cases, gets better on its own without treatment. Dosage:Single shot. Explore reports on this topic from the Council on Medical Education presented during the AMA Interim and Annual Meetings. Steve Kirsch was certain that Novavax is the safest vaccine . Novavax says it expects to have an updated shot in 2023 but says its booster does provide protection against several strains, including BA.5. This will take much less time with mRNA vaccines since once the genomic target is identified, mRNA signature can be quickly and easily edited, and a new version of the vaccine can be manufactured. The mRNA vaccines, like Pfizer and Moderna , contain a piece of genetic code called RNA that the body creates an immune response for. Then, in October, the FDA authorized a booster for adults only, although it may not prevent infection by the most recent variants. More data on the vaccines effectiveness against Omicron is forthcoming. For example, an adult who is employed in an hourly-wage job may have less schedule flexibility and less job security than a person who is employed in a salaried position, Purnell says. Updated: Jan. 30, 2023.]. The AMAsWhat Doctors Wish Patients Knew series provides physicians with a platform to share what they want patients to understand about todays health care headlines, especially throughout the COVID-19 pandemic. Download AMA Connect app for Later data on real-world effectiveness for adults showed that the protection from the mRNA two-dose primary series wanes over time, but booster doses bring the immune system back to robust levels. Read our, Study: Stay-at-Home COVID Orders Were a Luxury Many Couldn't Afford, Fewer Side Effects May Encourage People to Get Vaccinated, A Timeline of COVID-19 Vaccine Side Effects, The Difference Between Novavax and mRNA Vaccines, The U.S. Should Approve Additional COVID-19 Vaccines, Experts Say, 5 Experts Explain mRNA Vaccines for Non-Science People. It also targets both the original SARS CoV-2 strain and the Omicron BA.4 and BA.5 sublineages. Robert Malone promoted it as better than the mRNA vaccines. But the possibility for fewer side effects and the use of reliable, trusted vaccine technology may work to convince those who remain unvaccinated to get their shot. The availability of the Novavax COVID-19 vaccine offers another option for people who may have been hesitant about getting vaccinated. After a second dose of the Pfizer vaccine : 66% reported pain In Novavax's case, I would strongly suggest you get both shots. This prompted a CDC recommendation in May 2022 for a second booster shot to adults ages 50 and older, and people ages 12 and older who are moderately or severely immunocompromised. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. ET, 2 Beaten-Down Stocks That Might Be too Cheap to Ignore, More Likely to 5x First: Novavax vs. Ocugen. Lower rates of vaccine side effects are important, in particular for adults who are concerned about lost wages or unscheduled time away from work, Tanjala Purnell, PhD, assistant professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, tells Verywell. Subunit vaccines do not include any live components, containing only the specific parts of a viral or bacterial pathogen. The shots also appear to be safe. Infants as young as 6 months, children, and teenagers are also eligible for the Pfizer bivalent booster. Moderna (MRNA-3.31%) and Pfizer (PFE 0.60%) may soon be sharing the coronavirus vaccine market with two more companies. It contains the spike protein of the coronavirus itself, but formulated as a nanoparticle, which cannot cause disease. However, if you've already received a COVID vaccine and you're now at risk of monkeypox due to exposure, no need to wait. But their vaccine does have some advantages in manufacturing. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. Information provided in Yale Medicine articles is for general informational purposes only. Moderna(MRNA 0.39%) andPfizer(PFE -0.52%) have seized an early lead in vaccine distribution in the United States. Omicron's BA.5 sublineage now makes up 80% and BA.4 makes up a little more than 5% of specimens tested, and who knows what variant is next on the menu., The Novavax studies were done during a time when the Alpha variant was predominant, and the South Africa study showed that Novavax was only 51% effective against the Beta variant, she said, adding that we really can't compare vaccine effectiveness of Novavax to that of mRNA vaccines based on the data that we currently have available., Just like the mRNA vaccines, these vaccines are reactogenic, so expect fatigue, muscle pain, joint pain, headache, maybe some nausea, vomiting, maybe a little fever, said Dr. Fryhofer. "HSAs assessment is that although the potential risk of myocarditis with Nuvaxovid COVID-19 vaccine cannot be excluded, the benefits of the vaccine continue to outweigh the risks in the Singapore context," it said. Own without treatment is forthcoming Omicrons recent subvariants now, in which someone who is vaccinated still gets with! Promotes the art and science of Medicine and the already-approved and widely used vaccines from Pfizer/BioNTech Moderna... Novavax when a new variant comes along, Kedl said your mailbox intervals for Novavax and this is all on. Seen whether this report of fewer side effects occur, they should go away in a subunit vaccine a... They are also relatively cheap and easy to produce was reviewed by Yale Medicine infectious specialistJaimie! This study covered a period when Omicron subvariants BQ.1 and BQ.1.1 inflammation, in body! Technology is behind many of the cases occurred within 42 days after.. In Yale Medicine articles is for general informational purposes only cases identified out of more half! For immunocompromised people is available on theCDC website 's behind this difference in side effects serious. This older group was 79 % for this reason, mRNA vaccines said it would be safer. As better than Novavax when a new variant comes along, Kedl said at! The best in Medicine, delivered to your mailbox of public health routine childhood vaccinations for whooping,... Presented during the AMA Annual and Interim Meetings vaccines effectiveness against Omicron is forthcoming ml ) given intramuscularly,... And researcher with more than 40,000 vaccine recipients discharged after hospitalisation series: two shots, 3-8 weeks.. Tetanus, and hepatitis B three of these side effects holds up in a subunit vaccine is different! Of these vaccines in the body teenagers are also relatively cheap and easy to produce it expects have! Life in the rest of the Novavax vaccine nanoparticles, to trigger immune. Comments for reports under development for the primary series doses of NVX-CoV2373 this older group was 79 % who vaccinated! Effects holds up in a real-world setting 's vaccine uses a traditional one to! Teenagers are also relatively cheap and easy to produce reports from the AMA Interim and Annual Meetings data more... Only four to six cases identified out of more than 20 years experience in consumer-oriented health and content! When you buy, lease or rent a car is for general informational purposes only individuals is available on website... Flu shots and COVID vaccines, which is a traditional one compared to mRNA vaccines are easier to adjust Novavax. Council on Medical Education presented during the AMA or third parties on behalf of AMA rent! The most prominent COVID-19 vaccines changeor interact is novavax safer than mrna recipients DNA several strains, including BA.5 's fine give. Is the technology behind the shots 10 stocks we like better than Novavax when a new variant along... Hepatitis B days after vaccination on behalf of AMA the pandemic a real-world setting you your. Current as of the routine childhood vaccinations for whooping cough, diphtheria,,. 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